BRCA1 and breast cancer: The PRS for ER-negative women exhibited the highest correlation with BC risk in BRCA1 patients with an HR of 1.27 (95% CI = 1⁄4 1.23 to 1.31); also, BRCA2 carriers showed PRS for the risk of BC with HR = 1.22 (95% CI = 1.17 to 1.28), showing differences in absolute risks (more than 10% in each case) between the upper and lower deciles of the PRS curve [143].