BRIP1 and breast neoplasm: Germline analysis from 2160 early-onset breast tumor patients and 1199 ovarian cancer patients displayed that nearly 2% of these individuals carry very rare missense variants in BRIP1 (allele frequency < 0.0001), with a frequency that is three times higher than that of all rare BRIP1 missense variants found in over 60,000 subjects from general individuals (p < 0.0001).