SMAD4 and colorectal carcinoma: Of these, nine were highly expressed in CRC (FN1, FLT4, VEGFA, Wnt3, TGFB1, PDGFB, CCND1, TGFBR1, FAP), while seven were downregulated (PTEN, SMAD4, EGFR, ATG14, FZD5, NRAS, BRAF) (Supplementary Table S6; GSEA Figure S8 and Table S10).