Genetic alterations of GATA4, especially single nucleotide polymorphisms (SNPs), have been linked to CHDs in the human population, associations being made with atrial septal defects (ASDs), ventricular septal defects, atrioventricular septal defects, tetralogy of Fallot, pulmonary stenosis, and pulmonary atresia [46,47,48,49,50]. This evidence concerns the gene GATA4 and Pulmonary artery atresia.