NFKB1 and cancer: Mechanistically, NF-κB directly downregulates the anti-metastatic miR-488 and enhances special AT-rich sequence-binding protein-1 (SATB1) and Twist1 expression, the major initiators of the EMT, suggesting that the NF-κB/miR-488 axis is responsible for cancer cells migration and metastasis in presence of M2-TAMs [121].