Indeed, Gadd45b−/− HCC tumors, but not Gadd45b+/+ tumors, showed an enhanced F4/80+ and IBA1+ TAMs and T-cells infiltration as well as a higher number of tertiary lymphoid structures (TLSs), which are correlated to a favorable clinical outcome in most human cancers. Here, GADD45B is linked to hepatocellular carcinoma.