Congruently, mannose modified lipid nanoparticles (M-IMD-LNP), containing the NF-κB inhibitor IMD-0354, as well as hyaluronic acid (HA) nanoparticles, loaded with the micro-RNA miR-125, showed that M2 TAMs are able to repolarize toward the M1 phenotype, in an NF-κB dependent manner, both in melanoma cells and in an in vivo model of non-small cell lung cancer (NSCLC) [195,196]. This evidence concerns the gene NFKB1 and melanoma.