In vivo studies demonstrated that a ketogenic diet (KD) induces a strong p65 inhibition in both TAMs and CRC cells, that in turn, promotes TAMs M1 polarization and reduces tumor growth and metastasis, suggesting that NF-κB plays a role in the modulation of tumor metabolic adaptation and inflammatory response [132]. The gene discussed is NFKB1; the disease is colorectal carcinoma.