Chemoattractants, produced by malignant cells and the stromal tumor compartment, such as C-C Motif Chemokine Ligand 2 (CCL2), vascular endothelial growth factor (VEGF), CXCL12 (SDF1) and colony-stimulating factor-1 (CSF-1), recruit monocytes from the bloodstream that migrate into tumor site [5,6]. This evidence concerns the gene CXCL12 and neoplasm.