IL-33-stimulated TAMs show an increase in NF-κB-mediated Matrix metalloproteinase-9 (MMP9) expression, that in turn degrades the extracellular matrix protein laminin and allows the extravasation and dissemination of tumor cells, suggesting that the IL-33-NF-κB-MMP9-laminin axis moderates the CAF-TAM crosstalk to foster cancer metastasis [68]. This evidence concerns the gene IL33 and cancer.