Consistently, knockdown of CCN3 in PCa cells inhibits RAW264.7-promoted angiogenesis and tumor growth in mouse models, suggesting that CCN3 secreted by PCa cells regulates TAMs infiltration and function by modulating the FAK/Akt/NF-κB signaling pathway in macrophages [178]. Here, NFKB1 is linked to posterior cortical atrophy.