NFKB1 and hepatocellular carcinoma: In particular, the infiltration of M1 TAMs promotes the hyperactivation of NF-κB pathway, the increase in anti-apoptotic activity, the upregulation of the expression of cyclin-dependent kinase (CDK)1, CDK2 and cyclin D1, and the reduction of p21 expression in HCC cells, sustaining tumor proliferation.