NFKB1 and neoplasm: Moreover, the concerted activation of STAT1 and NF-κB pathways induces apoptosis of GBM cancer cells and increases iNOS and Iba1+ expression in the microglia, indicating the presence of activated M1 macrophages which eliminate the remaining GBM cells and apoptotic debris, and a tumor remission in 50–60% of treated mice [139].