Furthermore, Li and collaborators showed that a modified porous hollow iron oxide nanoparticles (PHNPs) loaded with a P13Kγ small molecule inhibitor (3-methyladenine, 3-MA), (PHNPs@DPA-S-S BSA-MA@3-MA), selectively inhibit the PI3Kγ/Akt signaling in TAMs by inducing a prolonged activation of NF-κB, through the reduction of the P13Kγ protein in macrophages and cancer cells, that in turn, promote the switch of TAMs toward pro-inflammatory M1 phenotype and the activation of immune response leading to reduced tumor growth and immunosuppressive TME [197]. This evidence concerns the gene AKT1 and neoplasm.