Regarding multiple myeloma (MM), HERV-K env and LTR increased expression was found as a distinctive characteristic between MM and monoclonal gammopathy of undetermined significance (MGUS) or controls, and their carcinogenic effect including, but not limited to, cell proliferation is mediated through the modification of the expression of tumor suppressive pathways, such as TP53 and CDKN1A, and the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3F, 3G, and 3H expression [70]. This evidence concerns the gene TP53 and Miyoshi myopathy.