FGFR3 and skin neoplasm: A study examining the different possible mutations associated with codon p.650 in FGFR3 observed that variants with significantly increased receptor kinase activity compared to the wild type [43] also had a strong expansion prevalence in somatic (e.g., skin tumors) and male germline tissue (e.g., testicular tumours, but were underrepresented in sperm [15].