In Brazil, mutations in the GJB2 gene are the leading cause of deafness in autosomal recessive inheritance, and the c.35delG mutation is the most common variant in many ethnic groups [78], where 1 in 51 Caucasians (1.9%) carries the c.35delG mutation, aligning closely with the rates observed in most European populations [97]. Here, GJB2 is linked to deafness.