VEGFA and diabetic foot: In the present study, the expression of VEGF was increased by treatment with htyr at doses of 10−5 M and 10−6 M. In this context, diabetic foot ulcers were successfully treated using nanoparticles of sesamol [3, 4-methylenedioxyphenol], a natural organic compound obtained from sesame oil, which achieved an acceleration of wound healing mediated by the co-expression of PDGF and VEGF [37].