Of note, we observed that hepatic MST4 levels positively correlate with the incidence and severity of MASH-driven HCC and that the depletion of MST4 markedly suppresses the proliferative, migratory, and invasive capacity as well as the epithelial–mesenchymal transition of human HCC cell lines [22]. This evidence concerns the gene STK26 and hepatocellular carcinoma.