In the present study, we assessed the effect of TIGAR KO on cardiac metabolism, pathological hypertrophy, and cardiac dysfunction in Ang-II-induced hypertension and showed that Ang-II decreased the expression of PFK-1 and Glut-4 in association with moderate cardiac hypertrophy, which was attenuated by the ablation of TIGAR. Here, SLC2A4 is linked to hypertrophy.