Of note, although studies were carried out in experimental CKD [100], acromegalic individuals [101,102] and individuals with poorly controlled type 1 diabetes mellitus [131], high growth hormone levels can be associated with glomerular hyperfiltration, hypertrophy and glomerulosclerosis (the latter more rarely in humans), and chronic administration of growth hormone for the treatment of growth hormone deficiency has not been associated with progression of chronic kidney disease [132,133,134]. This evidence concerns the gene GH1 and diabetes mellitus.