IRF8 and diffuse large B-cell lymphoma: Sworder et al. reported alterations in multiple classes of genes in DLBCL cells, including those related to B-cell identity (paired box 5(PAX5) and interferon regulatory factor 8 (IRF8)), immune checkpoints (CD274), and the microenvironment transmembrane protein 30A (TMEM30A), were associated with resistance [112].