Wang et al., utilizing genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screening, identified Ikaros family zinc finger protein 2 (IKZF2) and transducin-like enhancer of split 4 (TLE4) as potentially linked with the functional suppression and exhaustion of T-cells in GBM mode. Here, TLE4 is linked to glioblastoma.