CASP8 and leukemia: Notably, leukemia cells with a reduced expression of death receptor genes (Fas associated via death domain (FADD), BH3 interacting domain death agonist (BID), caspase 8 (CASP8), TNF receptor superfamily member 10b (TNFRSF10B)) have been associated with patients showing no response [95] (Figure 2A).