What is unknown is whether, once obesity and insulin resistance are established in PCOS, any intervention(s) to reverse these also positively impacts on the AD-risk proteins; however, this is inferred from the results that showed BMI correlated positively with APCS and apoE in PCOS women and that HOMA-IR correlated positively with apoE in PCOS women suggesting that, should weight and insulin resistance increase with an increased BMI, that these parameters would also increase. Here, APOE is linked to polycystic ovary syndrome.