APOE and obesity due to melanocortin 4 receptor deficiency: What is unknown is whether, once obesity and insulin resistance are established in PCOS, any intervention(s) to reverse these also positively impacts on the AD-risk proteins; however, this is inferred from the results that showed BMI correlated positively with APCS and apoE in PCOS women and that HOMA-IR correlated positively with apoE in PCOS women suggesting that, should weight and insulin resistance increase with an increased BMI, that these parameters would also increase.