In this study, those parameters associated with inflammation such as IL6 and the heat shock response proteins correlated with APP, SNCA and ApoE in the PCOS subjects but not the normal controls, suggesting that those with PCOS could be predisposed to enhanced changes of these proteins with the onset of inflammation induced by obesity and insulin resistance. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.