In a proteomic study used to analyze proteins in a comparison between AD, frontotemporal dementia (FTD) and controls, it was reported that five proteins, fibronectin (FN), fibronectin fragment 3 (FN1.3), fibronectin fragment 4 (FN1.4), Von Willebrand factor (VWF) and extracellular matrix protein 1 (ECM1) were discriminatory being increased in AD in comparison to both FTD and controls [22], and which may prove to be important biomarkers for AD in the future. This evidence concerns the gene ECM1 and Alzheimer disease.