As illustrated in the heatmap (Figure 1F), there were three genes that were significantly downregulated by colitis induction (TNBS + Veh) and restored after disease mice were treated with I3C (TNBS + I3C), which included one mucin protein (Muc2) and two goblet cell markers (Tff1 and Tff3). The gene discussed is MUC2; the disease is colitis.