We published a report showing indole-3-carbinol (I3C), a natural AhR ligand derived from cruciferous vegetables, was able to reduce colitis severity and disease-associated microbial dysbiosis, attributed predominately through the production of interleukin-22 (IL-22) by innate lymphoid type 3 (ILC3) cells [13]. The gene discussed is IL22; the disease is colitis.