The overarching goal of this study was to validate doxycycline-inducible FtH overexpression in an NSCLC model (H1299T FtH C11) and use this model system to evaluate the ability of T2* mapping to detect changes in FtH expression in vivo above the noise of other factors, such as H2O/fluid accumulation or necrosis [20]. Here, FTH1 is linked to non-small cell lung carcinoma.