According to the KM-plotter pan-cancer RNA-seq database for lung adenocarcinomas (n = 513), tumors with high TfR expression correspond to a significantly worse overall survival of 39 months compared with the 54 months of the low expression cohort (HR = 1.38; 95% CI = 1.02–1.87; p = 0.036) (Figure 1A) [15]. The gene discussed is TFRC; the disease is cancer.