PINK1 (PTEN-induced putative kinase 1) and Parkin (encoded by PARK2), encoding a mitochondrially targeted kinase and E3 ubiquitin ligase, respectively, have been implicated in Parkinson’s disease, with mutations in these genes causing autosomal recessive parkinsonism (Table 1) [57]. This evidence concerns the gene PRKN and Parkinson disease.