PRKN and Parkinson disease: Recent genome-wide association studies have highlighted loci associated with an increased risk for PD [18], with an increasing body of experimental evidence suggesting that these proteins affect the protein translation process, including leucine-rich repeat kinase 2 (LRRK2), eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), eukaryotic translation initiation factor 4E-binding protein (4E-BP), α-synuclein (SNCA), PTEN-induced kinase 1 (PINK1), and Parkin (PARK2), in a complex network (Table 1) [19].