SNCA and Parkinson disease: An alternative mechanism may be that key regulatory miRNAs (miR-7 and miR-153), which inhibit translation of the SNCA transcript through binding to its 3′-UTR, are downregulated; expression analysis of the substantia nigra of patients with PD shows a downregulation of miR-7 and miR-153, where the overexpression of these miRNAs reduced endogenous α-synuclein levels [95,96].