Considering the results of the enrichment, PPI, and post-enrichment analysis, we can conclude that the upregulated genes (COL5A2, MMP2, COL11A1, COL12A1, COL5A1, COL4A2, COL8A1, COL1A1, COL1A2, COL3A1, and COL6A1) and BST from the downregulated genes are related principally to the modulation of the extracellular matrix and that downregulated genes are associated mainly with the alteration of immune response mechanisms to viral infection (CCL5, TNF, IFIH1, MX1, OAS1, OAS2, RSAD2, and STAT1). The gene discussed is COL1A1; the disease is viral infectious disease.