When it comes to the interplay of lymphoma cells and the TME, BAFF, mainly produced by monocytes and dendritic cells [224], was shown to drive NLRP3 inflammasome priming and activation both in normal and neoplastic B-cells via the BAFF/BAFF-R axis [113], possibly contributing to the proliferation advantage and apoptotic resistance of malignant B-cell clones. The gene discussed is TNFRSF13C; the disease is lymphoma.