Considering that either NLRP3 or IL-18 inhibition in lymphoma mouse models leads to a decrease in PD-1/TIM-3-expressing T-cells, MDSCs, tumor-associated macrophages, and regulatory T-cells, it can be proposed that IL-18 mediates the accumulation of immunosuppressive cell populations [86]. The gene discussed is NLRP3; the disease is lymphoma.