Overall, studies exploring the role of NLRP3 inflammasome in the pathogenesis of AML report an upregulation in NLRP3-associated genes, namely NLRP3, ASC, CASP1, IL-18, and IL-1β, both in BMMNCs and PBMCs, though results for specific components present variations between studies [214,215]. The gene discussed is CASP1; the disease is acute myeloid leukemia.