For the case of B-cell NHLs, TRIM28 expression was positively and independently correlated with dismal patient survival, while in terms of pathophysiology, TRIM28 was demonstrated to contribute to B-cell NHL proliferation by increasing cyclinA and proliferating cell nuclear antigen (PCNA) expression and reducing P21 expression. Here, PCNA is linked to B-cell non-Hodgkin lymphoma.