It is noteworthy that for the case of melanoma it was shown that NLRP3 inflammasome activation elicits autocrine heat shock protein 70 (HSP70)/TLR4 signaling pathway inducing a Wnt family member 5A (Wnt5a)-dependent C-X-C motif chemokine ligand 5 (CXCL5)/C-X-C motif chemokine receptor 2 (CXCR2) secretion that recruits granulocytic MDSC [188]. The gene discussed is WNT5A; the disease is melanoma.