NLRP3 and hematologic disorder: TRIM proteins constitute one of the largest subfamilies of E3 ubiquitin ligases, which was shown to participate in NLRP3 inflammasome regulation at multiple levels via the ubiquitination of various substrates [134], while their dysregulation was associated with hematological malignancies [135], highlighting another possible link between NLRP3-related aberrations and lymphomagenesis.