Specifically, the downstream pathways induced upon IL-18 binding to IL-18R include those of NF-κB, phosphoinositide 3-kinase (PI3K)/Akt, and RAS/MAPK [94], all of which were shown to hold an integral role in the survival and proliferation of neoplastic cells in various lymphoma subtypes [176,177,178]. Here, IL18R1 is linked to lymphoma.