The positive correlation of TRIM28 expression in B-cell NHL tissues with inferior patient survival [168] could, therefore, be attributed to both its contribution to NLRP3 inflammasome activation [146] and the subsequent enhancement of lymphoma cell survival and proliferation (via pathways that will be analyzed in the following section), and its involvement in the regulation of cell cycle and p53-mediated apoptosis [168]. The gene discussed is TRIM28; the disease is B-cell non-Hodgkin lymphoma.