Moreover, though immediate correlations between BAFF levels and NLRP3 inflammasome activation were not studied in the setting of SS-related lymphomagenesis, it can be proposed that the increased BAFF levels, documented in SS patients with increased risk for lymphoma development or concomitant lymphoma [114], may predispose to lymphoma progression via BAFF-induced NLRP3 inflammasome activation in B-cells [113], as described previously. This evidence concerns the gene TNFSF13B and lymphoma.