Assessing the expression of NLRP1, NLRP3, AIM2, IL-1β, and IL-18 by immunohistochemistry in the epidermal and dermal layers of skin from Sézary syndrome patients, idiopathic erythroderma patients, and healthy donors, the researchers identified increased IL-1β and low IL-18 levels in the epidermal skin layers of Sézary syndrome patients compared to the control groups. The gene discussed is NLRP1; the disease is Sezary syndrome.