Therefore, it is believed that the implication of the NLRP3 inflammasome in both tumorigenesis and antitumor immunity is dependent on several factors, such as its levels of expression, its downstream effector molecules (i.e., IL-1β or IL-18), the cancer-type and stage, as well as the potential presence of genetic aberrations affecting its expression or function [20]. This evidence concerns the gene NLRP3 and cancer.