Additionally, increased TG2 immunoreactivity and its catalyzed crosslinks colocalize with Aβ in senile plaques, as well as in the vessel wall in early stage cerebral amyloid angiopathy (CAA), suggesting the involvement of TG2 early in the formation of these pathologic features in AD-affected brains [130,131,132]. This evidence concerns the gene TGM2 and Alzheimer disease.