In a neuroblastoma SH-SY5Y cellular model, increased TG2 activity and TG2-dependent α-Syn crosslinking were detected following exposure to the dopaminergic toxin 1-methyl-4-phenylpyridine (MPP (+)), while the pharmacological blockade of TG2 with Z006 was found to inhibit this effect [147]. The gene discussed is TGM2; the disease is neuroblastoma.