Though their temporal changes in terms of gene expression were milder, when compared to those of UBE3A or Nedd4L, large Herc members have recently gained relevance because when their encoding genes are mutated, they are associated with clinical syndromes closely related to NDDs, resulting in intellectual disability, dementia, epileptic seizures, and/or signs of autism [59]. This evidence concerns the gene NEDD4L and dementia.