Other effects of iron overloading in the hippocampus of the AD APP/PS1 mice model recently investigated [35] include an impact on the proprotein convertase Furin, which catalyzes the proteolytic maturation of a large number of prohormones and proproteins, and on the maturation of the brain-derived neurotrophic factor (BDNF). Here, APP is linked to Alzheimer disease.