Even though only α-synuclein is thought to be involved in the pathophysiology of PD, patients with DLB (dementia with Lewy bodies) have been found to have lower levels of the SNCB transcript, and in vitro studies indicate that β-synuclein may antagonize α-synuclein-induced aggregation and toxicity [235]. The gene discussed is SNCB; the disease is Lewy body dementia.