The allele of ADAM33 T2 may take part in the development of severe asthma by amplifying the mixed type of eosinophilic/type 2 and neutrophilic inflammation (the most severe endotype of asthma) since a significant association was found between this allele and serum IL-6 levels as well as higher blood neutrophil counts, which were emphasized in patients with eosinophilia type 2 inflammatory endotype [20]. Here, ADAM33 is linked to asthma.