For this, the authors utilized 9–10 weeks old apolipoprotein E-deficient (ApoE-/-) mice that were treated with angiotensin II (AngII, 1000 ng/kg/min) via aortic minipumps and in parallel fed with a HFD (2% cholesterol and 20% fat) for 28 days to foster the development of aortic aneurysms. Here, APOE is linked to aortic aneurysm.