Alzheimer’s disease, the major cause of dementia, shows a specific neuropathological characteristic: extracellular depositions of diffuse and neuritic plaques, formed by higher-order fibrils of amyloid beta (Aβ) released from cleaved β-amyloid precursor protein (APP) and the intracellular accumulation of neurofibrillary tangles composed of aberrantly hyperphosphorylated tau protein [2]. This evidence concerns the gene APP and Alzheimer disease.