APP and Alzheimer disease: In other studies on neurodegenerative diseases, it has been reported that HHT contributed to the amelioration of memory impairment and the reduction of neuroinflammation in APP/PS1 transgenic mice [33], and HHT inhibited the cognitive dysfunction and reduction in the plaque burden in 3XTg-AD mice through a significant decrease in the levels of detergent-soluble and acid-soluble Aβ [34].