The CDC73 gene encodes parafibromin, a protein that acts as a tumour suppressor; parafibromin interacts with different proteins through its C-terminal domain, being a part of the polymerase II-associated factor 1 (PAF1) complex that binds to RNA polymerase II and blocks cyclin D1 expression [11,12,13,14]. The gene discussed is CDC73; the disease is neoplasm.