SIPA1L2 and Parkinson disease: The third class displayed fluctuating trends in BMP levels; however, if only prodromal and PD cohorts were considered, the rs4771268 (MBNL2) and rs76904798 (LRRK2) were allocated to the first and second class, respectively, and rs896435 (ITGA8) and rs10797576 (SIPA1L2) were considered to be in the fourth class (Figure S3A–D).