The synergistic enhancement of VDD-induced differentiation of AML cells by Nrf2-activating compounds has been demonstrated in different human and murine AML cell lines [14,16,17,18,19,20] and patient-derived AML blasts [21,22] as well as mouse models of AML [18,23,28]. This evidence concerns the gene NFE2L2 and acute myeloid leukemia.