Chromosomal instability can give rise to the Vogelstein model of adenoma–carcinoma–metastasis in 70–90% of CRC cases, characterized by mutations in APC, TP53, and DCC (deleted in CRC), resulting in the inhibition of apoptosis, increased cell proliferation, and reduced cell adhesion [32]. The gene discussed is TP53; the disease is colorectal carcinoma.