Importantly, so far, the ADAMTS7 gene polymorphisms have not been studied in the context of CAD in the Polish population; therefore, the primary aim of this study was to investigate the impact of the rs1994016, rs3825807, and rs7173743 variants of the ADAMTS7 gene on the risk of CAD in the case–control model. The gene discussed is ADAMTS7; the disease is coronary artery disorder.