Next, we performed a colorectal cancer screening test in HFHSD-induced diabetic mice and ND-fed healthy mice with five consecutive miR-10a/b mimic injections at 5 months PI using the well-known tumor markers CEA and CA-19-9 [22], which are widely used in the diagnosis of colon cancer. The gene discussed is CEACAM5; the disease is colonic neoplasm.