The involvement of FLICR, a negative regulator of FOXP3 in Tregs, and NEST, which is taking part in activating the IFNG locus, suggests a possible role of these lncRNAs in MS-related immune regulation and inflammation, thus highlighting the importance of T cell-related lncRNAs in MS [143]. The gene discussed is IFNG-AS1; the disease is myeloid sarcoma.