The analysis of miRNA-mRNA interaction demonstrated that signaling pathways including B cell receptor, phosphatidyl-inositol-3-kinase (PI3K), and phosphatase and tensin homology (PTEN) were the most affected in MS patients [51], with also an enhancement of cytokines production, such as lymphotoxin and tumor necrosis factor α (TNF-α), due to an overexpression of miR-132 [52]. This evidence concerns the gene TNF and myeloid sarcoma.