In men, MS and most of its morbidities are related to low blood T [897,898,899]; a marked lack of enough T also results in lower dihydrotestosterone effectiveness [900] and a parallel decrease in E2, which [95,124] results in a further lack of control of the insulin–glucose system [898,901] and a decrease in the flow of 2C through the Krebs cycle (Section 4.2 and Section 4.3). This evidence concerns the gene INS and myeloid sarcoma.