The encoded L(3)mbt protein contains a novel malignant brain tumor (MBT) domain with three tandemly repeated MBT motifs at the amino terminal region, followed by a unique zinc finger motif (zf-HC/zf-C2) and the SPM/SAM (SCM, PH, and MBT homology/Sterile α motif) domain at the middle and carboxy terminal regions [68] (Figure 2). This evidence concerns the gene CREBZF and brain neoplasm.