The less common variants in MT-ATP6/8 or MT-ATP8 reported in the literature showed to cause maternally inherited diabetes and deafness syndrome [144], left ventricular hypertrabeculation [145], brain pseudoatrophy and mental regression [146], cardiomyopathy [39], autism [147], epilepsy [148], ataxia, peripheral neuropathy, diabetes mellitus, and hypergonadotropic hypogonadism [41]. The gene discussed is MCAT; the disease is cerebellar ataxia.