The aim of this study is to analyze the expression and topographic localization of FL-(P)RR, along with its ligands renin and prorenin, and its target COX-2 [4], in the kidneys of two mouse models of metabolic disorders (diabetes and metabolic syndrome) and a rat model of classic focal segmental glomerulosclerosis (FSGS), with the rat being of the Milan normotensive strain (MNS) [13,14,15]. This evidence concerns the gene REN and diabetes mellitus.