Univariate Cox regression analyses indicated that gender (male, HR = 0.793, p = 0.200), age (>60, HR = 1.205, p = 0.295), race (Black or African American, HR = 1.585, p = 0.290; White, HR = 1.323, p = 0.144), and AFP level (>400, HR = 1.075, p = 0.772) showed no prognostic significance, but pathologic T stage (T3 or T4, HR = 2.949, p < 0.001), pathologic stage (stage III or stage IV, HR = 2.823, p < 0.001), tumor status (with tumor, HR = 2.317, p < 0.001), and AURKB expression (high, HR = 1.549, p = 0.014) were connected to the OS of HCC patients. Here, AURKB is linked to hepatocellular carcinoma.