In fact, VEGF-A, together with ADH1A, CYP26A1, and VEGF-C, showed a common interaction in “signal transduction pathways” which are known to be dysregulated in HCC, with consequent uncontrolled cell division and metastasis [27], alteration of intracellular regulators or extracellular signals with abnormal epigenetic modification, and gene expression in the tumor microenvironment. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.