Thus, with this aim, we studied 5 known candidate SNPs in genes controlling tumor angiogenesis, VEGF-A (rs2010963), VEGF-C (rs4604006), HIF-1α (rs12434438), ANGPT2 (rs55633437), and NOS3 (rs2070744), and genotyped a subgroup of 23 HCC patients using the DMET plus platform to identify potential prognostic biomarkers correlated to HCC patient responses to sorafenib treatment. This evidence concerns the gene NOS3 and neoplasm.