Thus, with this aim, we studied 5 known candidate SNPs in genes controlling tumor angiogenesis, VEGF-A (rs2010963), VEGF-C (rs4604006), HIF-1α (rs12434438), ANGPT2 (rs55633437), and NOS3 (rs2070744), and genotyped a subgroup of 23 HCC patients using the DMET plus platform to identify potential prognostic biomarkers correlated to HCC patient responses to sorafenib treatment. Here, ANGPT2 is linked to hepatocellular carcinoma.