A study by Tan and colleagues observed that serum levels of miR-122-5p are elevated in PBC patients and suggested that a panel of three miRNAs (miR-122-5p, miR-141-3p, and miR-26b-5p) could be a more sensitive and specific marker than ALP and ANA to diagnose PBC. This evidence concerns the gene BTG3 and primary biliary cholangitis.