A meta-analysis of eight different studies has suggested an association between the HLA-DRB1 allele polymorphisms HLA-DRB1*07 and HLA-DRB1*12 and the risk of HCC, while HLA-DRB1*07, HLA- DRB1*12, and HLA-DRB1*15 alleles were associated with significantly increased risks of HCC in Asian populations [60]. This evidence concerns the gene HLA-DRB1 and hepatocellular carcinoma.