Elevated serum levels of NT-pro-BNP are observed in HF and during cardiac ischemia, pulmonary embolism, cor pulmonale, hypertension, hyperthyroidism, Cushing syndrome, hyperaldosteronism, cirrhosis, subarachnoid hemorrhage, and kidney failure. This evidence concerns the gene NPPB and Cushing syndrome due to macronodular adrenal hyperplasia.