NLRP3 and irritable bowel syndrome: In addition, the NLRP3 level (Figure 9D, IBS gut/degenerative brain axis) was also reduced by VitD3 NS compared with damage and other forms of VitD3 (50% vs. LPS 100 ng/mL + H2O2 200 μM, 19% vs. VitD3 Physical Mix 100 nM, and 17% vs. VitD3 Sigma 100 nM, p < 0.05).