ALDH2 and obesity due to melanocortin 4 receptor deficiency: Human genome-wide association studies (GWASs) and case–control investigations have highlighted that the ALDH2*1 WT allele, rather than the ALDH2*2 allele, is associated with a higher predisposition to metabolic syndrome, hypertension, diabetes, and obesity, particularly in males or individuals with alcohol consumption habits [33,34].