To assess the chronic impact of obesity on AF, wild-type (WT) and homozygous ALDH2*2 KI mice were subjected to either a high-fat diet (HFD: 60% fat, 20% protein, 20% carbohydrates) or a normal diet (ND: 10% fat, 20% protein, 70% carbohydrates) from 8 to 24 weeks of age. This evidence concerns the gene ALDH2 and obesity due to melanocortin 4 receptor deficiency.