SHBG and breast cancer: Using the MR method (this method allows to evaluate the cause-effect relationships between the studied features [37]), the relationship of SNPs and GWAS-associated with the level of SHBG [23] with the BC risk in postmenopausal women was shown; furthermore, an increase in the concentration of circulating SHBG (for every 25 nmol/L) led to a decrease in the risk of BC as a whole (OR = 0.94, p = 0.006) and ER-positive cancer (OR = 0.92, p = 0.003), but the risk of developing ER-negative tumors, on the contrary, increased (OR = 1.09, p = 0.047) [24].