Minor allele C rs10454142 PPP1R21, being in the woman genotype, raised the risk of BC by 15–16% for each allele (CC vs. TC vs. TT [additive model]; OR = 1.31; 95%CI = 1.08–1.65; p = 0.022; pperm = 0.024; power = 85.26%). The gene discussed is PPP1R21; the disease is breast cancer.