It should be noted that the liver is the site of SHBG synthesis [18] and, at the same time, as shown by our in silico data, rs10454142 PPP1R21 and strongly linked loci are functionally active in liver cells (localized in regions of histone proteins marking enhancers/promoters/active enhancers/active promoters associated with the GTF2A1L gene expression and correlated with the methylation of a number of genome sites in liver carcinoma). This evidence concerns the gene GTF2A1L and hepatocellular carcinoma.