Firstly, the contribution of rs10454142 PPP1R21 to disease susceptibility (0.32%) is the highest among all other seven BC-significant loci (from 0.04% for rs7910927 JMJD1C to 0.25% for rs8023580 NR2F2) and their paired interactions (the highest estimates reach 0.27%). This evidence concerns the gene PPP1R21 and breast cancer.