At the end of the discussion of the obtained materials, we consider it important to note that our work revealed significant regulatory effects of SHBG-significant BC-associated loci in fibroblasts in relation to 18 genes (eQTL [17 genes]: PPP1R21, ATRAID, AC074117.10, BRI3, BAIAP2L1, FOXN2, GPN1, MRPL35P2, JMJD1C-AS1, RP11-307C18.1, NRBF2, NRBP1, MSH6, JMJD1C, GTF2A1L, PRMT6, and SLC5A6; sQTL [2 genes]: FNDC4 and PPP1R21). The gene discussed is BRI3; the disease is breast cancer.