Sixth, rs10454142 PPP1R21 and all 10 strongly linked loci affect the level of methylation of a number of genome sites in blood, immunocompetent cells (CD14+ monocytes, native CD4 + T cells), liver (carcinoma), cerebral cortex, with predominant hypermethylation effects for the polymorphic variant C rs10454142 PPP1R21 (Supplementary Table S6). Here, CD4 is linked to carcinoma.