SHBG and breast cancer: At the same time, it should be noted that the results of numerous previous studies devoted to the study of the role of individual genetic determinants of SHBG in BC formation are ambiguous [25,26,27,28,29,30,31,32,33], and the contribution of individual GWAS significant for SHBG loci to BC susceptibility has not been studied; this determines the relevance of this work.