It was revealed that all 8 loci involved in the BC susceptibility influence the connection of regulatory DNA sites with 21 TFs (DMRT1, Evi-1, FAC1, Foxd1, Foxl1, Foxp1, Foxq1, GR, Hlx1, Hoxa9, INSM1, Mef2, Nanog, NFKB1, PLZF, Irf, Pou2f2, Pou3f3, Smad3, STAT, and TATA) (Supplementary Table S7). The gene discussed is MECOM; the disease is breast cancer.