The two-locus combination rs440837 ZBTB10-rs10454142 PPP1R21 was the basis for four BC-impacted models (44.44%), and the other two-locus combination, rs4149056 SLCO1B1-rs10454142 PPP1R21, was part of three BC-associated models (33.33%). Here, SLCO1B1 is linked to breast cancer.