ESR1 and breast cancer: Estrogens, as rules, realize their pathogenic effects in BC by interacting with their receptors (ER) through genomic (regulation of genes expression responsible for growth, differentiation, apoptosis, and angiogenesis) and non-genomic (interaction with various proteins, including adaptive proteins, G-proteins, growth factor receptors (EGFR, IGFR1, and HER2), cytoplasmic kinases (MAPKs, PI3K, and AKT), signaling enzymes (adenyl cyclase), etc.)and other mechanisms [53,57].