SHBG and breast cancer: For some limitations of this study, the following points can be highlighted: (a) the functional effects of BC-related loci assumed in the work based on in silico analysis need in vivo/in vitro experimental confirmation; (b) in this work, the levels of SHBG and sex hormones (testosterone, estrogens, etc.)were not determined, which would allow it to be more convincing to show that the biological pathways underlying the associations of the SNP candidate gene SHBG with BC.