As soon as androgens enter the cell, they connect with their receptors, while this complex (androgens–androgen receptors) detaches from heat shock proteins and transfers to the nucleus, where, interacting with various co-stimulators, co-repressors, and transcription regulators (miR-204, SOX-4, FOXA1, etc.), modulates the expression of a number of genes (HER3, MYC, PTEN, GPER, etc.)associated with the apoptosis, differentiation, angiogenesis, and proliferation of cells, including tumor cells (Wnt/β-catenin signaling pathway, PI3K/AKT, etc.)[48,49]. This evidence concerns the gene GPER1 and neoplasm.