SHBG and breast cancer: Using the Mendelian randomization (MR) method, it has been shown that, in the genetic correlation of SNPs and GWAS associated with the level of SHBG (determining ~8.4% of the genetic variability of the SHBG concentration in women) [23] with the risk of BC, the orientation of these associations (risk/protective) directly depended on the receptor status of the tumor [24].