These pattern studies of albino fish suggest that many genes, such as GPR143, TYR, OCA2, TYRP1, SLC45A2, SLC24A5, and C10RRF11, play important roles in the synthesis of fish eye pigments and that disturbances in their function lead to albinism and therefore may also be responsible for changes in fish eye color. The gene discussed is OCA2; the disease is albinism.