Additionally, the dephosphorylation of PDH activates its function, but the phosphorylation of PDH at distinct sites blocks its activity [30,31].As the gatekeeper complex for mitochondria respiration, inhibiting PDH activity by the upregulation of its phosphorylation through the downregulation of PDH phosphatase expression was validated and shown to decrease the OCR in glioblastoma [32]. This evidence concerns the gene PDP1 and glioblastoma.