NPM1 and acute myeloid leukemia: Therefore, the monitoring of DTA mutations by NGS does not appear to be informative, and this may also be the case for other genes commonly identified in age-related hematopoiesis, such as SRSF2, IDH1, and IDH2, for which NGS-based MRD has been shown to have no impact in predicting relapse in NPM1-mutated AML [80].