ABCB1 and acute myeloid leukemia: In AML, leukemic cells originate from a common progenitor known as a leukemic stem cell, possessing distinctive properties of quiescence, self-renewal, and the expression of specific survival genes (i.e., ABCB1/ABCC1/LRP [125]) rendering them particularly resistant to standard chemotherapies [126,127] such as daunorubicin or cytarabine [128].