TLR7 and Hepatic fibrosis: Not only cell-free HCV but also HCV-containing exosomes, isolated from patient sera, were shown to activate the TLR7/8 signaling pathways, so as to transfer HCV particles towards naïve hepatocytes, trigger monocytes differentiation towards macrophages producing mixed M1/M2 cytokines and having M2 surface markers, and, finally, promote the generation of circulating fibrocytes [106], thereby inducing liver fibrosis.