DNM1L and glaucoma: Consistently, Kim et al. showed in the DBA/2J mouse model of glaucoma that DRP1 inhibition, obtained by overexpressing DRP1 defective mutants, reduced both oxidation in RGCs and mitochondrial fission, suggesting a vicious cycle where exaggerated fission increased mitochondrial dysfunctionality, ROS production, and energy depletion [60].