MMP3 and osteoporosis: It is worth adding that Kwon et al.’s study also demonstrated the effectiveness of rosavin, zinc, and probiotic supplementation in reducing lower limb pain related to the musculoskeletal system and inhibiting inflammatory cytokines responsible for the development of both osteoarthritis and osteoporosis, i.e., matrix metallopeptidase 3 (MMP-3) IL-6, and TNF-α [49,52,53].