These results demonstrating significant upregulations in nonECRS and ECRS compared to the Ctrl and no difference between nonECRS and ECRS in PTAFR gene expression have been previously demonstrated [27] and suggest that clinical classification based on the JESREC criteria or status with/without comorbid asthma and/or AERD may be unrelated to PAF metabolism. The gene discussed is PTAFR; the disease is asthma.