However, due to the use of hierarchical analysis classification, the small sample size, and the limitation of these findings to Japanese patients, further research is needed to confirm our findings and the association between type 2 inflammation and the production of PAF-metabolism-associated proteins, including PAF and/or lyso-PAF, to continue the development of anti-PAF therapies for CRSwNP, especially those with severe type 2 inflammation. Here, PCLAF is linked to chronic rhinosinusitis with nasal polyps.